Minnesota led by as many as 15 in the second half.
Minnesota will be without its leading scorer for the remainder of the season.
The Cornhuskers handed the Gophers their first road loss of the 2019-20 season.
Minnesota is now 8-1 on the season and currently has an eight-game winning streak.
The Gophers beat American 70-53 behind a strong performance from Taiye Bello. The Gophers are now 7-1 on the season.
After the team struggled early in the fourth quarter, Gadiva Hubbard led the way for Minnesota late in the game.
The Gophers' early-season success has come on the back of a balanced offensive attack, with five players averaging double-digits points per game.
After getting three recruits to sign National Letters of Intent this month the Gophers have nabbed some of their players of the future.